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3 min read

Glutathione has been gaining a lot of attention lately, touted to help address skin care concerns such as hyperpigmentation and wrinkles. What is all the buzz behind what is called “the master antioxidant?” Here, we’ll explain what this ingredient is, and how to boost your glutathione for great looking skin.

Glutathione (GSH; γ-glutamyl-cysteinylglycine) is a tripeptide composed of glutamic acid, cysteine, and glycine found naturally within the skin that plays an important role in preventing oxidative damage. Glutathione is an antioxidant present in almost every cell in the body, playing a role in the detoxification of drugs. As a dietary supplement, it has many functions, such as improvement of liver, improvement of diabetic complication, protection from viral infection, and antitumor activity.

Researchers have found that glutathione is found in surprisingly high levels in most cells, the same concentration in cells as glucose, potassium, and cholesterol. Glutathione levels are highly associated with health and longevity, and it is also an indicator of other important metabolic activity. Some other critical roles assigned to glutathione in the body include:

  • Neutralization of superoxide radicals
  • Cofactor for several antioxidant enzymes
  • Regeneration of vitamins C and E
  • Neutralization of free radicals produced by liver metabolism of chemical toxins
  • Transportation of mercury out of cells and the brain
  • Regulation of cellular proliferation
  • Vital to mitochondrial function and maintenance of mitochondrial DNA (mtDNA)

Glutathione has been shown to be very important in helping prevent hyperpigmentation, helping to prevent melanogenesis, the generation of melanin in the skin. It’s postulated that its antimelanogenic properties result from a variety of mechanisms including stimulation of pheomelanin synthesis rather than darker eumelanin, its antioxidant effects, and interference with intracellular trafficking of melanin-causing enzymes. Glutathione also possesses certain antiaging properties.

How to incorporate glutathione into your skin care?

According to Dr. Natalya Fazylova, DNP of ReBalance Integrative Medicine and Anti-Aging Center in NYC treatments that combine both internal and external treatments show the best results. In her clinic, for example, they approach treating hyperpigmention by addressing hormonal imbalances, providing IV drips containing glutathione while also providing skin care.

According to Lydia Sarfati, CEO and Founder of Repêchage Skin Care, glutathione is essential to helping metabolize everything in your body internally. Still, externally, it is a super potent antioxidant as well helping in the purification and detoxification of the skin. The ingredient is particularly effective when combined with other bio-active ingredients, such as Laminaria Digitata seaweed extract, which contains 12 multiple vitamins, and amino acids, including Glutathione (GSH) precursors cysteine, glycine, and glutamic acid, among 15 other amino acids as well as antioxidants and 42 mineral and trace elements. Diminished GSH synthesis caused by deficiency of its precursors cysteine and glycine is an essential contributor to GSH deficiency. Research has found this  to be corrected by supplementing these amino acids in the diet, from foods such as broccoli, avocados, spinach and asparagus.   

An effective treatment would include an at-home sheet mask that incorporates Glutathione, Laminaria Digitata, Ascophyllum Nodosum, Arbutin, Diglucosyl Gallic Acid, Sodium Hyaluronate, Willow Bark Extracts, and Licorice Root Extracts to infuse skin with brightening ingredients that help lessen the appearance of hyperpigmentation and uneven skin tone. Glutathione inhibits the tyrosinase enzyme switching the melonogenesis  process from eumelanin to the lighter phaeomelenin. Leave on for 10-15 minutes. For an even more effective at-home treatment, and to enhance the benefits of these ingredients, use an at-home LED device set on Yellow/Amber for brightening or on Green, which is great for dark spots and discoloration. for a maximum time of seven minutes.

This at-home treatment can be done up to three times a week to create a beautiful, even-toned complexion.  

These treatments need to be maintained on a daily basis with the proper skin care regimen that incorporates ingredients such as Laminaria Digitata seaweed extract, which contains the amino acids of GSH precursors cysteine, glycine and glutamic acid. This seaweed extract is the cornerstone ingredient to the full line of Repêchage products, but is found at its highest levels in C-Serum ® Seaweed Filtrate. This facial serum for all skin types is an intensive concentrate of our exclusive, nutrient-rich, sustainably-harvested Laminaria Digitata Seaweed extract.

Using C-Serum® Seaweed Filtrate in combination with the Biolight® Brightening Collection can significantly improve the clarity and the appearance of an even tone of the skin.

What are some of the ways you create at-home facial treatments? Let us know in the comments below.

*This blog is for informational purposes only and is not intended as medical advice, diagnosis or treatment. Always seek the advice of your doctor or qualified health provider with any questions or concerns you may have about a medical condition or treatment and before beginning any medical treatment.


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